Vancomycin and daptomycin pharmacodynamics differ against a site-directed Staphylococcus epidermidis mutant displaying the small-colony-variant phenotype.

نویسندگان

  • Marina Wu
  • Christof von Eiff
  • Nahed Al Laham
  • Brian T Tsuji
چکیده

Catheter-related bloodstream infections due to slow-growing Staphylococcus epidermidis small-colony variants (SCVs) are extremely difficult to treat. Daptomycin and vancomycin pharmacodynamics were evaluated against a site-directed hemB mutant of S. epidermidis displaying the SCV phenotype and compared to that of the parental strain. The maximal killing effect decreased by 7.7-fold for vancomycin and 1.5-fold for daptomycin against the SCV mutant and were well characterized by a Hill-type mathematical model (R2 > 0.97).

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 53 9  شماره 

صفحات  -

تاریخ انتشار 2009